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Warning! This page contains information regarding Star Trek: Discovery, and thus may contain spoilers.
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Gamma Serpentis was a star system located in the Alpha Quadrant; it was close to the heart of Federation space.
In 2384, Asencia plotted the course of the USS Protostar to a restricted sector near Gamma Serpentis. (PRO: "Mindwalk")
Unfortunately, Asencia was able to activate the living construct when she contacted the Dauntless. The construct was able to spread its corruption to the USS Dauntless and other Starfleet ships that arrived in response to its distress signal. Despite assistance from the Federation's allies, such as the Klingons, Ferengi, and Gorn. The construct continued to corrupt Starfleet's vessels as they destroyed themselves and their allies. Realizing the situation would otherwise end with Starfleet's annihilation and seeing no other way to remove the construct, the Protostar's crew elected to destroy their ship. The ship, under the command of Hologram Janeway, was destroyed along with the construct, ending the signal as there was no longer a source. (PRO: "Supernova, Part 1", "Supernova, Part 2")
In 3191, this system's location was labeled in a star chart. (DIS: "Red Directive")