The Virgin and Child with St. Anne
According to Christian tradition, Saint Anne was an ancient Human who was the mother of Mary and the grandmother of Jesus Christ.
Saint Anne was depicted in Leonardo da Vinci painting The Virgin and Child with St. Anne, which was also found among the relics in Kathryn Janeway's da Vinci holodeck program. (VOY: "Scorpion", "The Raven", "Scientific Method", "Concerning Flight")