The Irish Setter was a breed of domesticated dog, originating from Ireland, on Earth.
In 2369, Q turned Doctor Beverly Crusher into an Irish Setter when he had an argument with her. Amanda Rogers immediately turned her back into a Human. (TNG: "True Q")
In 2371, Captain Kathryn Janeway owned a female Irish Setter named Mollie, who had puppies shortly after her owner left Earth to command the USS Voyager. (VOY: "Caretaker", "Hunters")
In 2373, Q tried to persuade Captain Janeway to mate with him by conjuring a puppy. The female Q later referred to Janeway as "that dog". (VOY: "The Q and the Grey")
Beverly Crusher as an Irish Setter
Mollie, Janeway's Irish Setter
An Irish Setter puppy