A chemical sprayer was a type of device used to apply chemicals in the form of a mist, such as weed spray.
During a rescue mission on Phylos in 2269, the landing party consisting of James T. Kirk, Hikaru Sulu, and Leonard McCoy, came armed with chemical sprayers containing McCoy's home-brewed version of his great-great granddaddy's weed spray, which they used to neutralize attacking swoopers and aid in their rescue of Spock. (TAS: "The Infinite Vulcan")