Santiago was seemingly the leader of las Arañas deep within the Amazon Jungle of Peru.^[1]

After Constance Webb was shot by Ezekiel Sims and left for dead, Santiago and las Arañas tried to save her life. Although Cassie was born without any physical disabilities, Constance died.^[1]

Thirty years later, Cassie returned to Peru where she was met by Santiago, who explained her powers and the death of her mother.^[1]

Like other las Arañas, Santiago seemingly has some spider-like powers including:

• Superhuman Strength
• Superhuman Speed
• Superhuman Stamina
• Superhuman Durability
• Superhuman Agility
• Superhuman Equilibrium
• Superhuman Reflexes
• Limited Clairvoyance

• Santiago was portrayed by José María Yazpik in Madame Web.