While bonded to Harry Osborn, the venom symbiote spawned an offspring and bonded it to Mary Jane Watson before pitting it against Spider-Man.

MJ was able to free herself from the alien, which withered and died without a host.^[1]

Scream is the manifestation of Mary Jane's worst repressed feelings. She is violent, sadistic, temperamental and hostile. Much of her anger comes from how she feels about Peter, as she believes he cares more about being Spider-Man than he pays attention to her. She also feels that many of her dreams have been left aside and that no one cares about her achievements. Despite everything, a small part of her true self was still there, managing to save herself with Peter's help.

Symbiote Biology:

• Superhuman Strength
• Superhuman Speed
• Superhuman Agility
• Superhuman Stamina
• Superhuman Reflexes
• Superhuman Durability
• Regenerative Healing Factor
• Wallcrawling
• Genetic Memory
• Constituent-Matter Generation
• Constituent-Matter Manipulation (Hair): The Scream symbiote allowed MJ to extend her hair-like tendrils to lash at or encircle her foes.
• Hive Mind: The symbiote had access to the symbiotes hive mind, enabling it to communicate with other symbiotes as well as their hosts and through the symbiote, MJ can too.
• Size Alteration: MJ was able to grow bigger using the scream symbiote.
• Shape Alteration: The Scream symbiote allowed MJ to enlarge her arms and form sharp claws and talons on her hands and feet so that she could better hurt Spider-Man.
• Fire Immunity: The Scream symbiote was completely immune to fire and extreme heat.

• High-frequency Sounds: The symbiote is extremely weak to high-frequency sounds produced by sources such as alarms to church bells, which can cause the alien and its host to experience extreme pain. Prolonged exposure could kill the symbiote or even cause the host to separate itself from the alien with enough willpower.

• The symbiote is voiced by Morla Gorrondona, Caitlin Hutson, and Yoko Soumi in Marvel's Spider-Man 2.