I want him dead! I want him to know that it was the Guild that ended him! Above all -- I want him to suffer! And... just because he's pissed me off... anyone associated with Wade Wilson dies, too... starting with his handler and the traitor, Threnody. 
Appearing in 1st story
Featured Characters:
- Deadpool/Venompool (Wade Wilson) (Temporarily bonds to the Venom symbiote)
Supporting Characters:
- Threnody (Melody Jacobs)
- Weasel (Jack Hammer)
- Clarice Hammer (First full appearance)
Antagonists:
- Assassins Guild
- Belladonna (Bella Donna Boudreaux)
- Blackout (Cameo)
- Bushwacker (Carl Burbank)
- Boomerang (Fred Myers) (Only on screen as a static image or video record)
- KIA (Michael van Patrick) (Only on screen as a static image or video record)
- Scorpia (Elaine Coll) (Only on screen as a static image or video record)
- Crossbones (Brock Rumlow) (Only on screen as a static image or video record)
- Lord Deathstrike (Only on screen as a static image or video record)
- Mimeyoshi (Only on screen as a static image or video record)
- Jack O'Lantern
- Black Mamba (Tanya Sealy) (Only on screen as a static image or video record)
- Numerous unnamed acolytes (Death)
- Man-Thing (Ted Sallis) (Cameo)
- Mojo News Network (Cameo)
- Mojo (Cameo)
- Major Domo (Cameo)
- Unidentified other
- Amazons (Cameo)
- Warrior Woman (Hippolyta) (Cameo)
- Numerous unidentified others
- The Hand (Cameo)
- Eddie Brock (Cameo)
- Unnamed wizard
- Monsters of Evil (Cameo)
- Ghost Rider (Danny Ketch) (Cameo)
Other Characters:
- Project Gladiator (Referenced)
- Mr. Knight (Marc Spector) (Cameo)
- Doctor Strange (Stephen Strange) (Mentioned)
- Torgo (Cameo)
- Cammi Benally (Cameo)
- Mr. the Troll (Pip Gofern) (Cameo)
- Planet Terry (Cameo)
- Ora (Cameo)
- Rhino (Aleksei Sytsevich) (Cameo)
- Avengers Unity Division (Mentioned)
- Numerous unnamed mercenaries (First appearance)
- Benjamin Franklin (Drawing)
Races and Species:
- Mutants
- Lilin
- Cyborgs
- Humans
- Robots
- Man-Things
- Spineless Ones
- Androids
- Human-Olympian Hybrids
- Hellbent
- Symbiotes
- Rats
- Mekkans
- Laxidazians
- Kree
- Unidentified alien species
- Monsters
- Demons
- Zombies
- Dogs (Mentioned)
Locations:
- Earth
- United States of America
- Louisiana
- Florida
- New York
- New York City
- Manhattan
- Midtown
- New York City Sewer System
- Mojo News Network
- New York City Sewer System
- Midtown
- Queens
- Staten Island
- Manhattan
- Hellhouse (First appearance)
- New York City
- Nevada
- Hellhouse, Chicago, Illinois (Mentioned)
- Mediterranean Sea
- Canada (Mentioned)
- Atlantic Ocean
- United States of America
- Hell (Invoked)
Items:
- Scorpion Battle Suit (As hologram)
- Jack O'Lantern's Suit
- Deadpool's Suit and Katanas
- Sallis' Modified Serum SO-2 Formula
- Super-Soldier Serum (Referenced)
- Mr. Knight's Suit
- Venom symbiote
- Darkhold (Referenced)
- Sorrow-Blade (First appearance)
- Kree Militia Uniform
- Fifty Shades of Grey (Mentioned) (Topical Reference)
- Ghost Rider's Chain
- Rhino Armor
- Pumpkin Bombs
Vehicles:
- Hell Cycle
- Jack O'Lantern's Flying Broomstick
- Taco Mama Food Truck (First appearance)
Synopsis for 1st story
- Synopsis not yet written
Solicit Synopsis
• Deadpool isn’t usually known for his attention to detail and promptness, but he’s CLEANING UP in the mercenary-for-hire biz.
• And since the Regeneratin’ Degenerate’s proven elusive of the Assassins Guild’s efforts to stop him, in this issue they’ll hit him where it hurts…
• His groin. His friends.