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CDH17

From Wikipedia, the free encyclopedia

CDH17
Identifiers
AliasesCDH17, CDH16, HPT-1, HPT1, cadherin 17
External IDsOMIM: 603017; MGI: 1095414; HomoloGene: 56859; GeneCards: CDH17; OMA:CDH17 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144663
NM_004063

NM_019753

RefSeq (protein)

NP_001138135
NP_004054

NP_062727

Location (UCSC)Chr 8: 94.13 – 94.22 MbChr 4: 11.76 – 11.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[5][6][7]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079112Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028217Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
  6. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
  7. ^ a b "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".

Further reading

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