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CDH15

From Wikipedia, the free encyclopedia
CDH15
Identifiers
AliasesCDH15, CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
External IDsOMIM: 114019; MGI: 106672; HomoloGene: 3622; GeneCards: CDH15; OMA:CDH15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004933

NM_007662

RefSeq (protein)

NP_004924

NP_031688

Location (UCSC)Chr 16: 89.17 – 89.2 MbChr 8: 123.57 – 123.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.[5][6]

Function

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This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.[6]

Interactions

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CDH15 has been shown to interact with ARVCF.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129910Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031962Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
  6. ^ a b "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".
  7. ^ Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.

Further reading

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