The BePRECISE (Better Precision-data Reporting of Evidence from Clinical Intervention Studies & Epidemiology) consortium, comprising 23 experts in precision medicine, cardiometabolic diseases, statistics, editorial and lived experience, provides a checklist tool and recommendations for reporting precision medicine research.

Juliane Fonseca de Oliveira is a mathematician at CIDACS in Salvador, Bahia, Brazil. She describes her part in building an epidemiological model to analyze the diverse populations within the 100 Million Brazilians Cohort.

Shivani Misra describes how meeting a misdiagnosed patient early in her career led her to study precision diabetes in underrepresented groups.

Fortunate Machingura heads CeSHHAR Zimbabwe’s Climate, Environment, and Health Department and is also a lecturer at the Liverpool School of Tropical Medicine. She describes her pivot from HIV research to another crucial challenge facing Africa: climate change.

SARS-CoV-2 variant-specific neutralizing antibodies (nAbs) mediate protection against infection by the cognate variant to distinct extents, while the majority of protection elicited by natural infection is not mediated by nAbs.

A natural experiment of over 200,000 people who received a shingles vaccine revealed that the recombinant vaccine is associated with lower risk of dementia than the live vaccine, within 6 years of vaccination

In two preregistered studies involving 2,280 participants using simulated clinical scenarios, advice labeled as involving AI was evaluated as significantly less reliable and less empathetic compared with ‘human’-labeled advice.

In this large interventional, randomized controlled trial, structured and individualized exercise in patients with metastatic breast cancer led to lower levels of fatigue and improved health-related quality of life.

Trained on 1.5 million whole-slide images from 100,000 patients, a pathology foundation model is shown to improve performance of specialized models in detection of rare cancers.

Proteomic prediction models developed using a large-scale dataset from the UK Biobank Pharma Proteomics Project were superior to clinical models for assessing the 10-year risk of 67 diseases across different types of pathology, including multiple myeloma, motor neuron disease, pulmonary fibrosis, celiac disease and dilated cardiomyopathy.

As growing evidence shows that engagement with politics is associated with worsening mental and physical health, a bumper election year and increasing polarization could affect millions.

A translational study and phase 1 trial show that the JAK inhibitor ruxolitinib stimulates responses to nivolumab in patients with refractory Hodgkin lymphoma.

As healthcare becomes more data-driven and precise, promising greater accuracy, targeted use of resources and healthier populations, we ask what it will take to realize these benefits in local and global contexts.

Shivani Misra describes how meeting a misdiagnosed patient early in her career led her to study precision diabetes in underrepresented groups.

Precision health in low- and middle-income countries should focus on disease prevention and implementation in order to be cost-effective and impactful.