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The efficacy of a B-cell-lymphoma-2-homology-3 mimetic can be predicted by profiling the rewired status of the network of interactions among proteins of the B-cell-lymphoma-2 family via single-molecule pull-down and co-immunoprecipitation.
A systematic implementation of six efficiency optimizations for prime editing led to high levels of functional correction, in airway epithelial cells, of the predominant mutation that causes cystic fibrosis.
The clinical detection of fluorescent protoporphyrin IX during glioma-resection surgery can be improved via a microscope that pairs stimulated Raman histology and two-photon excitation fluorescence microscopy.
Desired cell-state transitions can be guided via the activation of gene expression through a constitutively expressed endoribonuclease whose translation is regulated by endogenous cell-state-specific miRNAs.
An optimized head-mounted fluorescent mesoscope enables large-scale calcium imaging at single-neuron resolution in freely moving mice, facilitating neurobehavioural studies during social interactions and fear-conditioning experiments.
A method leveraging antibodies conjugated with barcoded DNA strands to linearize closely spaced interactions from individual 3D protein complexes allows for the mapping of pairwise and higher-order protein interactions within cells.
A digital pathology–artificial intelligence framework that leverages active learning and clinician-in-the-loop real-time feedback improves performance in diagnostic tasks.
Recreation of the truncated form of the erythropoietin receptor in human haematopoietic stem and progenitor cells via Cas9-mediated genome editing gives the edited cells and their erythropoietic progeny a proliferative advantage.
Recombinases generated by phage-assisted evolution enhance the efficiency of the prime-editing-assisted targeted integration of large genes in mammalian cells.
The intestinal mucosal barrier can be reinforced via the oral administration of commensal bacteria coated with poly(ethylene glycol) to facilitate their penetration into mucus.
An automated perfusable microfluidic bioreactor can generate clinical doses of viable CAR T cells that are functionally comparable to cells produced in standard open-culture systems.
Cytidine deaminases with high editing efficiencies, diverse editing windows and increased ratios of on-target to off-target effects can be discovered via structure-based generative machine learning.
Subcutaneously injected biomaterial scaffolds mimicking key features of physiological T-cell activation enhance the antitumour activity of intravenously pre-administered CAR-T cells.
The functions of non-coding regulatory elements can be systematically studied genome-wide at high throughput in human cells via their Cas9-mediated deletion through libraries of paired single-guide RNAs targeting both ends of each element.
Multilingual articulatory representations in the speech-motor cortex of a participant with vocal-tract and limb paralysis enabled the development of a bilingual speech neuroprosthesis.
Extracellular vesicles decorated with an antibody-binding moiety specific for the fragment crystallizable domain can be used as a modular delivery system for targeted cancer therapy.
A spatial multi-omics method with high decoding capacity and reduced sequencing and imaging costs enhances the high-throughput detection of gene mutations, allele-specific expression and RNA modifications in tissue samples.