Cradle

🧪 Harmen & Daan would like to share our learnings on the Darwin Assembly method for gene mutagenesis, highlighting its advantages for efficiently and cost-effectively creating gene variants that produce desired proteins. While we ultimately chose a different path, we believe our insights and experiences can benefit others in the field. We openly discuss both the method's strengths and the challenges we encountered during our research and experimentation, aiming to contribute to the growing body of knowledge in protein engineering and assist fellow researchers in making informed decisions about their own projects. 👉 https://lnkd.in/evKj2N89

👩🏻🔬 In the second part of our assay development series, we share expert tips for handling challenging scenarios. Learn how to employ "enzyme teamwork" when your substrate or product can't be easily measured, and discover the power of in vivo assays for studying membrane-bound proteins. We also address common hurdles in protein expression and purification, offering practical solutions to improve solubility and quantification. From coupling enzymes to using GFP tags, these strategies can help you overcome obstacles and obtain cleaner, more reliable data. Our goal is to equip you with the tools and mindset to approach assay development as an exciting puzzle rather than a daunting task 👇 https://lnkd.in/dkZPwjGA

🫶 Interview with Franziska, our first Employee!

🫵 We are hiring engineers in Amsterdam! Come build the future with us: a web app to design tiny, biological machines, that can be used to manufacture almost anything and cure diseases.

We, Michelle Vandeloo and Jinel Shah, have written two blog posts on the art of assay development. The first one contains insights from our lab, the second one will contain tips and tricks on developing great assays. Developing enzyme assays doesn't have to be an intimidating task reserved for specialized biochemists. In our latest blog post, we break down the process into five approachable steps, from getting to know your enzyme to implementing quality control measures. We dive into the different types of assay readouts, explaining the pros and cons of absorbance, fluorescence, and bioluminescence measurements. You'll also get a refresher on enzyme kinetics and the Michaelis-Menten curve, with practical tips on how to use this information to improve your enzyme's properties. Whether you're new to assay development or looking to refine your skills, this post offers valuable insights to help you create scalable, robust assays. We believe that with curiosity and a basic understanding of enzymes, anyone can embark on this creative scientific journey. Read the full post to start developing your own enzyme assays with confidence! 👉 https://lnkd.in/efQk7429

🏆 We are proud to announce that Cradle has been nominated for VentureBeat's prestigious AI Innovation Award in the "Best Implementation of Generative AI (Health)" category.

🫵 We need your help designing better software for scientists! How? Connect with Sytske Besemer (You recently read how she went from prison to working on proteins: https://lnkd.in/eNNhNcdS) to tell her about your work! 🫶 👇

We may be biased, but this is likely the coolest commercial role in Life Science + Machine Learning domain. You will use your scientific background and commercial acumen to put Cradle into the hands of biotech R&D teams around the globe. Apply now at jobs.cradle.bio, or tell your friends! https://lnkd.in/enq9Nt7s #businessdevelopment #accountexecutive #commercial #SaaS #growth #proteinengineering #ML #AI

Cradle + Google We're excited to announce our new partnership with Google Cloud, aimed at providing an unprecedented level of security for our customers' sensitive research and development data. By leveraging Google Cloud's advanced data protection solutions, we've created a secure environment that allows our customers to innovate with AI, without compromising the safety of their valuable intellectual property. At Cradle, we view data security as primarily an engineering challenge. Our approach integrates safeguards at every architectural level, from each Cradler's device to our SaaS platform's web interface. This sets us apart in the biotech industry, where many focus primarily on perimeter security and compliance. While we're adopting SOC2 and ISO27001 standards, we believe true data security requires more comprehensive measures. Our collaboration with Google Cloud allows us to focus on what we do best - advancing our AI algorithms and developing our platform for protein engineering. We can now offer our customers a user-friendly, web-based software that makes protein engineering faster, cheaper, and more successful across various industries, all while ensuring the utmost protection of their intellectual property. We're proud to bring this level of security to the biotech industry. 👉 https://lnkd.in/eZbrU-UG

🫶 "From Prisons to Proteins: The Unexpected Journey of a UX Researcher" - our latest blog post chronicles Sytske Besemer's remarkable career path. From criminology to tech giants like Uber and Facebook, and now to biotech, Sytske's journey is a testament to the power of diverse experiences. We explore how Sytske's background, spanning academia, Silicon Valley, and even San Quentin prison, shapes her unique approach to UX research at Cradle. Her work now bridges the gap between AI experts and biologists, making cutting-edge protein design technology more accessible and effective. 👉 https://lnkd.in/eNNhNcdS