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CAMK1

From Wikipedia, the free encyclopedia

CAMK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK1, CAMKI, calcium/calmodulin dependent protein kinase I, CaMKI-alpha, CaM kinase I alpha
External IDsOMIM: 604998; MGI: 1098535; HomoloGene: 117458; GeneCards: CAMK1; OMA:CAMK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003656

NM_133926

RefSeq (protein)

NP_003647
NP_003647.1

NP_598687

Location (UCSC)Chr 3: 9.76 – 9.77 MbChr 6: 113.31 – 113.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.[5][6]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134072Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030272Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. doi:10.1002/j.1460-2075.1995.tb00037.x. PMC 394442. PMID 7641687.
  6. ^ a b "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

Further reading

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