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(pyruvate dehydrogenase (acetyl-transferring))-phosphatase

From Wikipedia, the free encyclopedia
[pyruvate dehydrogenase (lipoamide)] phosphatase
Identifiers
EC no.3.1.3.43
CAS no.9073-70-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

The enzyme [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) catalyzes the reaction

[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O [pyruvate dehydrogenase (acetyl-transferring)] + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.

References

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  • Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ (1972). "α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart". Arch. Biochem. Biophys. 148 (2): 327–42. doi:10.1016/0003-9861(72)90151-8. PMID 4401694.
  • Reed LJ, Damuni Z, Merryfield ML (1985). "Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Curr. Top. Cell. Regul. Current Topics in Cellular Regulation. 27: 41–9. doi:10.1016/b978-0-12-152827-0.50011-6. ISBN 9780121528270. PMID 3004826.