Acute neurocognitive effects of epigallocatechin gallate (EGCG)
- PMID: 22127270
- DOI: 10.1016/j.appet.2011.11.016
Acute neurocognitive effects of epigallocatechin gallate (EGCG)
Abstract
Green tea is reported to have wide ranging beneficial health outcomes across epidemiological studies, which have been attributed to its flavonoid content. We investigated whether the flavonoid epigallocatechin gallate (EGCG) modulates brain activity and self-reported mood in a double-blind, placebo controlled crossover study. Participants completed baseline assessments of cognitive and cardiovascular functioning, mood and a resting state electroencephalogram (EEG) before and then 120 min following administration of 300 mg EGCG or matched placebo. EGCG administration was associated with a significant overall increase in alpha, beta and theta activity, also reflected in overall EEG activity, more dominant in midline frontal and central regions, specifically in the frontal gyrus and medial frontal gyrus. In comparison to placebo the EGCG treatment also increased self-rated calmness and reduced self rated stress. This pattern of results suggests that participants in the EGCG condition may have been in a more relaxed and attentive state after consuming EGCG. This is in keeping with the widespread consumption of green tea for its purported relaxing/refreshing properties. The modulation of brain function due to EGCG is deserving of further controlled human studies.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Similar articles
-
Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double-blind, placebo-controlled, crossover investigation.Hum Psychopharmacol. 2012 Mar;27(2):177-86. doi: 10.1002/hup.1263. Hum Psychopharmacol. 2012. PMID: 22389082 Clinical Trial.
-
Antihypertensive effect of Benifuuki tea containing O-methylated EGCG.J Agric Food Chem. 2010 Feb 10;58(3):1903-8. doi: 10.1021/jf904335g. J Agric Food Chem. 2010. PMID: 20078079 Clinical Trial.
-
The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells.Biochem Biophys Res Commun. 2007 Aug 17;360(1):233-7. doi: 10.1016/j.bbrc.2007.06.030. Epub 2007 Jun 14. Biochem Biophys Res Commun. 2007. PMID: 17585882
-
Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis.Nutr Rev. 2014 Aug;72(8):507-22. doi: 10.1111/nure.12120. Epub 2014 Jun 19. Nutr Rev. 2014. PMID: 24946991 Review.
-
Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate.Amino Acids. 2010 Feb;38(2):519-23. doi: 10.1007/s00726-009-0411-z. Epub 2009 Dec 3. Amino Acids. 2010. PMID: 19956995 Review.
Cited by
-
Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review.Nutrients. 2024 Apr 26;16(9):1298. doi: 10.3390/nu16091298. Nutrients. 2024. PMID: 38732545 Free PMC article. Review.
-
Effects of green tea and roasted green tea on human responses.Sci Rep. 2024 Apr 13;14(1):8588. doi: 10.1038/s41598-024-59383-y. Sci Rep. 2024. PMID: 38615105 Free PMC article.
-
Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-α-syn mice.Biomed Pharmacother. 2024 Apr;173:116370. doi: 10.1016/j.biopha.2024.116370. Epub 2024 Mar 8. Biomed Pharmacother. 2024. PMID: 38458012 Free PMC article.
-
Acute effects of (-)-gallocatechin gallate-rich green tea extract on the cerebral hemodynamic response of the prefrontal cortex in healthy humans.Front Neuroergon. 2023 Nov 27;4:1136362. doi: 10.3389/fnrgo.2023.1136362. eCollection 2023. Front Neuroergon. 2023. PMID: 38234497 Free PMC article.
-
Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.Nutrients. 2023 Dec 6;15(24):5018. doi: 10.3390/nu15245018. Nutrients. 2023. PMID: 38140277 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources