Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis
- PMID: 17597571
- PMCID: PMC7106401
- DOI: 10.1016/S1473-3099(07)70160-3
Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis
Erratum in
- Lancet Infect Dis. 2007 Sep;7(9):580
Abstract
Echinacea is one of the most commonly used herbal products, but controversy exists about its benefit in the prevention and treatment of the common cold. Thus, we did a meta-analysis evaluating the effect of echinacea on the incidence and duration of the common cold. 14 unique studies were included in the meta-analysis. Incidence of the common cold was reported as an odds ratio (OR) with 95% CI, and duration of the common cold was reported as the weighted mean difference (WMD) with 95% CI. Weighted averages and mean differences were calculated by a random-effects model (DerSimonian-Laird methodology). Heterogeneity was assessed by the Q statistic and review of L'Abbé plots, and publication bias was assessed through the Egger weighted regression statistic and visual inspection of funnel plots. Echinacea decreased the odds of developing the common cold by 58% (OR 0.42; 95% CI 0.25-0.71; Q statistic p<0.001) and the duration of a cold by 1.4 days (WMD -1.44, -2.24 to -0.64; p=0.01). Similarly, significant reductions were maintained in subgroup analyses limited to Echinaguard/Echinacin use, concomitant supplement use, method of cold exposure, Jadad scores less than 3, or use of a fixed-effects model. Published evidence supports echinacea's benefit in decreasing the incidence and duration of the common cold.
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Comment in
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Benefit of echinacea for the prevention and treatment of the common cold?Lancet Infect Dis. 2008 Jun;8(6):346-7; author reply 347-8. doi: 10.1016/S1473-3099(08)70107-5. Lancet Infect Dis. 2008. PMID: 18501849 No abstract available.
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References
-
- National Institute of Allergy and Infectious Diseases The common cold, health matters fact sheets. http://www3.niaid.nih.gov/healthscience/healthtopics/colds/overview.htm (accessed May 30, 2007).
-
- Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Advance data from vital and health statistics; number 343. National Center for Health Statistics; Hyattsville, Maryland: 2004. - PubMed
-
- Caruso TJ, Gwaltney JM., Jr. Treatment of the common cold with echinacea: a structured review. Clin Infect Dis. 2005;40:807–810. - PubMed
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