Third Rock Ventures’ Post

In chronic inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease, a robust communication network involving macrophages and inflammatory fibroblasts within inflamed intestinal tissues is unveiled by single-cell RNA-sequencing and spatial transcriptomics. This comprehensive approach has highlighted the potential significance of myeloid and stromal cell subsets in understanding the diverse symptom presentation and treatment responses. A great study by Alba Garrido-Trigo, et al. on Nature Genetics “Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease”. #crohnsdisease #ulcerativecolitis #scRNA #BioTuring Read the publication here: https://lnkd.in/gdW6mwQ9 Explore the dataset on Talk2Data now: https://lnkd.in/gqGiZ8kA

Take a look at the observational, genetic and mechanistic evidence that has put Lp(a) in the spotlight as a heart disease risk factor – with Professor John Chapman on Lpa Forum >> https://lnkd.in/e5SD_PZH #Lpa #lipoproteina #heartdisease #CVD #ASCVD #lipidologists #cardiologists

Excited to share our paper that came out in Disease Models and Mechanisms on the role of HBS1L in retinal dystrophy. https://lnkd.in/enydzVy9 Here is the write up on the paper published on inventUM https://lnkd.in/eFBtP4Vd

"Prevalence of Genetic Variants and Deep Phenotyping in Patients with Thoracic Aortic Aneurysm and Dissection: A Cross-Sectional Single-Centre Cohort Study", publiziert in JCM Special Issue "Diagnosis and Management of Aortic Diseases: Drafting from Theoretical Aspects to Clinical Practice" https://lnkd.in/eZVgsvBK Ich danke allen Netzwerkpartnern, gemeinsam stehen wir für innovative Gefäßmedizin 😷

How old is your heart? We looked at genetic differences and risk factors that affect the age of the heart and circulation. Our new paper in Nature Communications points to genes regulating inflammation and stress response. #whyCMR #aging https://lnkd.in/gfPyzf2r

🧐 #MeetTheSpeaker! 🔬 How can we effectively combine genetics and health records to devise better public health policies? Andrea Ganna, associate professor at the University of Helsinki and Group Leader at the Institute of Molecular Medicine of Finland, is researching the use of polygenic risk scores to identify individuals at high risk of cardiovascular diseases and breast cancer.

𝗪𝗼𝗻𝗱𝗲𝗿𝗳𝘂𝗹 𝘁𝗼 𝘀𝗲𝗲 𝘁𝗵𝗲 𝗶𝗺𝗽𝗮𝗰𝘁𝗳𝘂𝗹 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝘁 𝘁𝗵𝗲 𝗩𝗶𝗰𝘁𝗼𝗿 𝗖𝗵𝗮𝗻𝗴 𝗖𝗮𝗿���𝗶𝗮𝗰 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲! 🌟 Dr. Chai Ann (Andy) Ng is making groundbreaking progress in diagnosing and treating inherited heart disorders using our SyncroPatch 384 system. Their high-throughput genetic test for Long QT Syndrome is revolutionizing the study of genetic variants, delivering faster and more accurate results for patients. Read more about Dr. Ng's story below 👇 #CardiacResearch #GeneticTesting #Arrhythmias #APC #Electrophysiology

Resonant supports Rare Disease Day! Did you know that approximately 1 in 10 people in the US are affected by rare disease? Because funding and patients are limited in rare diseases, studying and developing diagnostics and treatments is incredibly challenging. But because aproximately 80% of rare diseases have a genetic basis, advancements in DNA sequencing technologies in recent decades are revolutionizing diagnoses and improving therapeutics for many conditions. We are extremely optimistic this trend will continue—to ensure a brighter future for those living with rare disease! For the most up-to-date information about genetic and rare diseases, visit the National Institutes of Health's Genetic and Rare Disease Information Center at: https://lnkd.in/gQvEfy5t #rarediseaseday2024 #rarediseases #neurodegenerativediseases #als #alsawareness #diagnostics

NEW DATA ALERT! Benefit from consistent, defined and scalable human iPSC-derived disease model cells to study the impact of mutations related to Alzheimer’s and Parkinson’s in human CNS cells? Explore our latest poster to see the characterisation and functional data of our ioDisease Model Cells™ for Alzheimer’s disease. https://hubs.ly/Q02pkz1Z0 The disease model cells show protein expression of key markers. The ioMicroglia™ APOE 4/4 and TREM2 R47H Het disease models also show reduced phagocytic activity compared to the genetically matched wild-type control. #research #DrugDiscovery #AlzheimersDisease #ParkinsonsDisease #microglia #glutamatergic #neurons #science #data #optiox #ioCells #ioDiseaseModelCells

#Adrenoleukodystrophy #ALD #Genomics Here is an interesting paper currently being researched on ALD (Adrenoleukodystrophy) disease: The study titled "Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy" investigates the impact of ABCD1 deficiency on demyelination and neurological damage using a cuprizone mouse model. It found that while ABCD1 deficiency accelerates oligodendrocyte loss and axonal damage, it does not significantly affect the microglial or astrocyte function in myelin clearance or remyelination. This study highlights the role of ABCD1 in exacerbating demyelination but also shows that remyelination potential remains intact despite the genetic deficiency. Mouse model : CPZ For a basic introduction to ALD (Adrenoleukodystrophy), please check out the following video link! https://lnkd.in/gAJ7nJNC https://lnkd.in/gMgg56e7