About
Articles by Dr. Prasun
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GenAI: Revolutionizing Healthcare and Life Sciences
GenAI: Revolutionizing Healthcare and Life Sciences
By Dr. Prasun Mishra
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Revolutionizing Drug Discovery: Unleashing AI and Generative Modeling for Molecular Innovation
Revolutionizing Drug Discovery: Unleashing AI and Generative Modeling for Molecular Innovation
By Dr. Prasun Mishra
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Navigating the Cutting Edge: Recent Trends in Precision Medicine
Navigating the Cutting Edge: Recent Trends in Precision Medicine
By Dr. Prasun Mishra
Activity
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Excited about the BePRECISE guideline, published in Nature Medicine, which sets the first international standard for reporting precision medicine…
Excited about the BePRECISE guideline, published in Nature Medicine, which sets the first international standard for reporting precision medicine…
Liked by Dr. Prasun Mishra
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Excited about the BePRECISE guideline, published in Nature Medicine, which sets the first international standard for reporting precision medicine…
Excited about the BePRECISE guideline, published in Nature Medicine, which sets the first international standard for reporting precision medicine…
Shared by Dr. Prasun Mishra
Experience & Education
Licenses & Certifications
Publications
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MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity
Scientific Reports – Nature
Gill P, Bhattacharyya S, McCullough S, Dweep H, Mishra PJ, Luo C, Letzig L, James L (2017)
Other authorsSee publication -
Keratinocyte Induced Differentiation of Mesenchymal Stem Cells into Dermal Myofibroblasts: A Role in EffectiveWound Healing
International Journal of Translational Science
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Receptor tyrosine kinase AXL is upregulated in metformin resistant prostate cancer cells
Oncotarget
Nitu Bansal, Prasun J. Mishra, Mark Stein, Robert S. DiPaola, Joseph R. Bertino
(Keywords: Axl receptor tyrosine kinase, metformin, prostate cancer, Axl, drug resistance, personalized medicine)Other authors -
A MicroRNA Binding Site SNP Leads to Drug Resistance and Cellular Transformation
Book: Published by Rutgers University. 272 pages
Prasun J Mishra
(Keywords: drug resistance, single nucleotide polymorphism, 3' UTR, translational
regulation, mRNA stability, personalized medicine, microRNAs, miR-24, cell proliferation, cell cycle, gene regulation, cellular transformation, cell cycle arrest, dihydrofolate reductase, DHFR, methotrexate, antifolate, chemotherapy, polymorphism, 3' UTR, human colorectal cancer tumors, p53) -
A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance.
Proceedings of the National Academy of Sciences of USA. 2007 Aug 14;104(33):13513-8. Epub 2007 Aug 8.
Prasun J. Mishra, Rita Humeniuk, Pravin J. Mishra, Giuseppe S. A. Longo-Sorbello, Debabrata Banerjee, and Joseph R. Bertino
(Keywords: drug resistance, single nucleotide polymorphism, 3' UTR, translational
regulation, mRNA stability, personalized medicine)Other authorsSee publication -
A traitor in our midst: mesenchymal stem cells contribute to tumor progression and metastasis.
Future Oncology 2008 Dec;4(6):745-9. doi: 10.2217/14796694.4.6.745.
Prasun J. Mishra and Glenn Merlino
(Keywords: Tumor microenvironment, SDF-1, myofibroblast, cancer fibrosis, migration, differentiation, personalized medicine)Other authors -
Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity.
Leukemia. 2007 Dec;21(12):2399-405.
Humeniuk R, Menon LG, Prasun J Mishra, Saydam G, Longo-Sorbello GS, Elisseyeff Y, Lewis LD, Aracil M, Jimeno J, Bertino JR, Banerjee D
(Keywords: Aplidine, araC, drug combination, personalized medicine, mitochondria, hematological malignancies)Other authorsSee publication -
Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders
Blood. 2015 Jan 29;125(5):793-802.
Arun Balakumaran, Prasun J. Mishra, Edyta Pawelczyk, Sayuri Yoshizawa, Brian J Sworder, Natasha Cherman, Sergei A. Kuznetsov, Paolo Bianco, Neelam Giri, Sharon A. Savage, Glenn Merlino, Bogdan Dumitriu, Cynthia E. Dunbar, Neal S. Young, Blanche P. Alter, Pamela G. Robey
(Keywords: Dyskeratosis congenita and telomere biology disorders, bone marrow skeletal stem/progenitor cell, BMSCs, MSCs, TBDs, hematopoiesis, TERC, fibrosis, genomics, personalized medicine).Other authorsSee publication -
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells.
Cancer Research. 2008 Jun 1;68(11):4331-9.
Pravin J Mishra*, Prasun J Mishra* (* jointly first authored), Rita Humeniuk, Daniel J Medina, Gabriela Alexe, Jill P Mesirov, Sridhar Ganesan, John W Glod, Debabrata Banerjee
(Keywords: Tumor microenvironment, SDF-1, myofibroblast, cancer fibrosis, migration, differentiation, personalized medicine)Other authorsSee publication -
Cell-free derivatives from mesenchymal stem cells are effective in wound therapy.
WJ Stem Cells 05/2012; 4(5):35-43.
Pravin J Mishra, Prasun J Mishra, Debabrata Banerjee
(Keywords: Stem cell derivatives, Keratinocyte, Mesenchymal stem cell, Cytokine secretion, Wound healing, SDF1, ENA78, fibrosis, animal models, personalized medicine)Other authorsSee publication -
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Molecular Cancer Therapeutics 05/2009; 8(5):1037-44.
Humeniuk R, Menon LG, Prasun J Mishra, Gorlick R, Sowers R, Rode W, Pizzorno G, Cheng YC, Kemeny N, Bertino JR, Banerjee D
(Keywords: UMP Kinase, fluoropyrimidine, cancer, DNA methylation inhibitor, antineoplastic agent, diagnosis, drug resistance, promoter methylation, chemotherapeutic agent, personalized medicine)Other authorsSee publication -
Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.
Oncogene 04/2011; 30(15):1850-1850.
Prasun J Mishra, L. Ha, J. Rieker, E. V. Sviderskaya, D. C. Bennett, M. D. Oberst, K. Kelly, G. Merlino
(Keywords: Anchorage-independent growth, BRaf; cRaf, melanoma, NRas, PI3K, RalGEF, personalized medicine)Other authors -
Effect of Single and Recurrent Gamma Irradiation on in vitro Cultures
IJF Science 12/2007; 7(1):47-57.
Prasun J. Mishra, T. R. Ganapathi, P. Suprasanna, V. A. Bapat
(Keywords: Phenotypic screening, mutations, gamma rays, recurrent irradiation, induced mutagenesis, genetic engineering)Other authorsSee publication -
Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.
Molecular Cancer Therapeutics 05/2009; 8(5):1045-54.
Humeniuk R, Prasun J Mishra, Bertino JR, Banerjee D
(Keywords: UMP Kinase, fluoropyrimidine resistance, cancer, DNA methylation inhibitor, antineoplastic agent, promoter methylation, diagnosis, drug resistance to treatment, chemotherapeutic agent, personalized medicine)Other authorsSee publication -
Heparin and Suramin Alter Plitidepsin Uptake Via Inhibition of GPCR Coupled Signaling
Journal of Chemotherapy (Florence, Italy) 10/2009; 21(5):550-557.
G S A Longo-Sorbello, H Gao, Prasun J Mishra, B Kamen, A Soto, J Jimeno, M Aracil, M F Paz de Paz, J R Bertino, D Banerjee
(Keywords: Plitidepsin, Aplidium albicans, Aplidine, personalized medicine, multiple myeloma, renal cell carcinoma, melanoma, neuroblastoma, leukemia, lymphoma, suramin, heparin)Other authors -
Human salivary alpha-amylase Trp58 situated at subsite -2 is critical for enzyme activity.
Eur J Biochemistry 2004 Jun;271(12):2517-29.
Ramasubbu N, Ragunath C, Mishra PJ, Thomas LM, Gyémánt G, Kandra L
(Keywords: salivary a-amylase, site-directed mutagenesis, subsite engineering, personalized enzymology, oligosaccharide hydrolysis, crystal structure)Other authorsSee publication -
Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.
Journal of Biological Chemistry 07/2005; 280(24):22721-31.
Skacel N, Menon LG, Prasun J Mishra, Peters R, Banerjee D, Bertino JR, Abali EE
(Keywords: DHFR, dihydrofolate reductase; MTX, methotrexate; NADPH, personalized medicine, site directed mutagenesis, personalized enzymology, drug resistance, chemotherapy)Other authorsSee publication -
Improved Antitumoral Treatments
Patent: US 2010/0240595
Prasun J Mishra, along with Mishra Pravin J and Longo GSA, Jimeno J, Aracil M, Poplin E, Bertino JR and Banerjee D, inventors
(Keywords: Methods for the treatment of disorders, cancer, Aplidine, Gemcitabine, fibrosis, diagnosis, drug resistance, chemotherapy, personalized medicine)Other authorsSee publication -
Induction of Protein Downstream of Internal Ribosomal Entry Site (IRES) by antifolates treatment
Patent Provisional: 2010/5418
Prasun J Mishra, along with Banerjee D, Bertino JR and Mishra Pravin J, inventors
(Keywords: Bicistronic vectors, dihydrofolate reductase, DHFR, personalized medicine, methotrexate, fusion protein, rapamycin, cap dependent, cap independent translation)Other authorsSee publication -
Mesenchymal stem cells: flip side of the coin.
Cancer Research 04/2009; 69(7):3240-3240.
PJ Mishra, Prasun J Mishra, JW Glod, D Banerjee
(Keywords: Tumor microenvironment, SDF-1, myofibroblast, cancer fibrosis, migration, differentiation, personalized medicine)Other authorsSee publication -
MicroRNA Polymorphisms
Encyclopedia of Life Sciences (eLS) 04/2013; 15 APR(2013):1-15.
Prasun J Mishra, Rita Humeniuk
(Keywords: miRNAs, MOA, miR-polymorphisms, miRNA polymorphism, drug resistance, drug response, disease progression, diagnosis, personalized medicine)Other authorsSee publication -
MicroRNA polymorphisms: a giant leap towards personalized medicine
Personalized Medicine 03/2009; 6(2):119-125.
Prasun J Mishra
(Keywords: Diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine) -
MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.
Pharmacogenomics. 2009 Mar;10(3):399-416.
Prasun J Mishra and Joseph R Bertino
(Keywords: Classification, diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine)Other authors -
MicroRNA reexpression as differentiation therapy in cancer.
The Journal of Clinical Investigation 09/2009; 119(8):2119-23.
Prasun J. Mishra and Glenn Merlino
(Keywords: miRNAs, miR-1, miR-206, differentiated rhabdomyosarcoma, RMS, personalized medicine, skeletal muscle, myogenic differentiation, differentiation therapy, oncogenes, tumor development, fibrosis)Other authors -
MicroRNAs as promising biomarkers in cancer diagnostics.
BMC Biomark Research 2014 Oct 22;2:19.
Prasun J Mishra
(Keywords: Biomarker, circulating microRNAs, diagnostics, miRNA, miRNA polymorphisms, microvesicles, exosomes, pharmacogenomics, precision medicine, prognosis, variants, personalized medicine) -
MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism.
PLoS One. 2009 Dec 24;4(12):e8445.
Prasun J. Mishra, Bo Song, Pravin J. Mishra, Yuan Wang, Rita Humeniuk, Debabrata Banerjee, Glenn Merlino, Jingfang Ju, Joseph R. Bertino
(Keywords: MicroRNAs, miRNAs, miR-24, personalized medicine, cell proliferation, cell cycle, gene regulation, cellular transformation, G2/S cell cycle arrest, dihydrofolate reductase, DHFR, methotrexate, antifolate, chemotherapy, polymorphism, 3' UTR, human colorectal cancer tumors, p53-independent cell cycle inhibitory miRNA)Other authors -
MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics.
Cell Cycle. 2008 Apr 1;7(7):853-8.
Prasun J. Mishra, Pravin J. Mishra, Debabrata Banerjee and Joseph R. Bertino
(Keywords: Diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine)Other authors -
Modulation of Drug Sensitivity
Patent: US20100151004
Prasun J Mishra, along with Banerjee D, Bertino JR, Humeniuk R, inventors
(Keywords: Methods for the treatment of disorders, cancer, DNA methylation inhibitor, antineoplastic agent, diagnosis, drug resistance to treatment, chemotherapeutic agent, personalized medicine)Other authorsSee publication -
Molecular profile of clonal strains of human skeletal stem/progenitor cells with different potencies
Stem Cell Research 02/2015; 9.
Brian J. Sworder*, Sayuri Yoshizawa*, Prasun J. Mishra* (* jointly first authored), Natasha Cherman, Sergei A. Kuznetsov, Glenn Merlino, Arun Balakumaran, Pamela G. Robey
(Keywords: Single colony-derived cells, human bone marrow stromal cells, differentiation, gene expression, fibrosis, multipotent, non-multipotent strains, personalized medicine)Other authorsSee publication -
Molecular targets for epigenetic therapy of cancer.
Current Pharmaceutical Biotechnology 03/2009; 10(2):161-5.
Humeniuk R, Prasun J Mishra, Bertino JR, Banerjee D
(Keywords: Drug resistance, epigenetic therapy, chromatin modifications, DNA methylation, personalized medicine, combination chemotherapy)Other authorsSee publication -
Non-coding RNAs as clinical biomarkers for cancer diagnosis and prognosis
Expert Review of Molecular Diagnostics 11/2014; 14(8):917-9.
Prasun J Mishra
(Keywords: Biomarker, circulating microRNAs, diagnostics, miRNA, miRNA polymorphisms, microvesicles, exosomes, pharmacogenomics, precision medicine, prognosis, variants, personalized medicine) -
Pharmacogenomics of microRNA: a miRSNP towards individualized therapy.
Pharmacogenomics 01/2008; 8(12):1625-7.
Joseph R Bertino, Debabrata Banerjee, Prasun J Mishra
(Keywords: Diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine)Other authors -
Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase.
Journal of Molecular Biology 01/2003; 325(5):1061-76.
Ramasubbu N, Ragunath C, Prasun J Mishra
(Keywords: salivary amylase, crystal structure, complex, mobile loop, starch hydrolysis, enzyme, oligosaccharides, HPLC separation, enzyme kinetics, personalized enzymology, catalysis, glucose formation, site-directed mutagenesis)Other authorsSee publication -
Structure-function relationships in human salivary alpha-amylase: role of aromatic residues
Biologia 01/2005; 60:47-56.
Ramasubbu N, Ragunath C, Sundar K, Prasun J Mishra, Gyémánt G, Kandra L
(Keywords: Salivary α-amylase, site-directed mutagenesis, subsite engineering, personalized enzymology, oligosaccharide hydrolysis,crystal structure)Other authorsSee publication -
The mechanism of salivary amylase hydrolysis: role of residues at subsite S2'.
Biochem Biophys Res Commun. 2002 Mar 29;292(2):468-73.
Prasun J Mishra, Ragunath C, Ramasubbu N
(Keywords: amylase; enzyme, oligosaccharides, HPLC separation, enzyme kinetics, personalized enzymology, catalysis, glucose formation, site-directed mutagenesis)Other authorsSee publication -
The miRNA-drug resistance connection: a new era of personalized medicine using noncoding RNA begins.
Pharmacogenomics 09/2012; 13(12):1321-4.
Prasun J Mishra
(Keywords: Diagnosis, disease, drug resistance, epidemiology, genetic variation, genomic medicine, individualized medicine, microRNA, miRNA, miRSNP, mutations, ncRNA, noncoding RNA, personalized medicine, pharmacogenomics, polymorphisms, prognosis) -
The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy.
Expert Opinion on Biological Therapy 08/2007; 7(7):965-73.
Picinich SC, Mishra PJ, Prasun J Mishra, Glod J, Banerjee D
(Keywords: diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine) -
Translational modulation of proteins expressed from bicistronic vectors.
Molecular Imaging 12/2009; 8(6):305-18.
Prasun J. Mishra, Lata G. Menon, Pravin J. Mishra, Philipp Mayer-Kuckuk, Joseph R. Bertino, and Debabrata Banerjee
(Keywords: Bicistronic vectors, dihydrofolate reductase, DHFR, personalized medicine, methotrexate, fusion protein, rapamycin, cap dependent, cap independent translation)Other authors -
Use of Stem Cells for Wound Healing and Anti-Cancer Therapy
Patent: 20110020291, Year: 01/2011
Prasun J Mishra, along with Banerjee D, Mishra Pravin J, Bertino JR, Humeniuk R, Glod JW, inventors
(Keywords: Cell therapy, compositions, MOA, stem cell delivery, fibrosis, cell free concentrate, accelerated wound healing, personalized medicine, normal and chronic wounds, scar tissue)Other authorsSee publication
More activity by Dr. Prasun
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Are you or someone you know passionate about Grant Writing and Partnerships? If so, you may find the following position interesting. DM me if you are…
Are you or someone you know passionate about Grant Writing and Partnerships? If so, you may find the following position interesting. DM me if you are…
Posted by Dr. Prasun Mishra
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The following position looks interesting. If you are interested in learning more, please send me a direct message. Director, Operations, Compliance…
The following position looks interesting. If you are interested in learning more, please send me a direct message. Director, Operations, Compliance…
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Did you know that some people have never caught COVID-19? A new study might explain why! 🌟 Research published in the June 2024 issue of Nature…
Did you know that some people have never caught COVID-19? A new study might explain why! 🌟 Research published in the June 2024 issue of Nature…
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