The Human Genome Project captured the public’s imagination with its global quest to better understand the genetic blueprint stored on the DNA within our cells. The project succeeded in delivering the first-ever sequence of the human genome while foreshadowing a future for medicine once considered to be science fiction. The project presaged the possibility that healthcare could be personalized based on clues within a patient’s unique genetic code. Scientists at Sanford Burnham Prebys are employing new technologies and expertise to test ways to improve diagnoses and customize treatments for many diseases based on unique characteristics within tumors, blood samples and other biopsies. “I think we’ve gotten a lot better at precision diagnostics,” says Lukas Chavez, PhD, an assistant professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys. “In my work at Rady Children’s Hospital in cancer, we can characterize a tumor based on mutations, including predicting how quickly different tumors will spread. What we too often lack, however, are better treatment approaches or medicines. That will be the next generation of precision medicine.” Read more: https://bit.ly/4cTm1d7 #precisionmedicine #humangenome #genomesequencing #artificialintelligence #computationalbiology
Sanford Burnham Prebys
Research Services
La Jolla, CA 14,821 followers
We conduct world-class, collaborative, biological research and translate discoveries for the benefit of patients.
About us
Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding basic human biology and disease and advancing scientific discoveries to profoundly impact human health. Our track record of pioneering research spans more than 40 years and has produced breakthroughs in cancer, neuroscience, immunology and children’s diseases and is anchored by our NCI-designated Cancer Center. Sanford Burnham Prebys’ drug discovery center and global partnerships propel our prototype drugs and therapeutic strategies toward improving human health. A deep culture of collaboration and commitment to educating the next generation of scientists unites Sanford Burnham Prebys researchers, partners and philanthropists in a shared mission to improve human health.
- Website
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http://www.sbpdiscovery.org
External link for Sanford Burnham Prebys
- Industry
- Research Services
- Company size
- 501-1,000 employees
- Headquarters
- La Jolla, CA
- Type
- Nonprofit
- Founded
- 1976
- Specialties
- stem cells, drug discovery, cancer research, diabetes research, rare and neglected diseases, neurodegenerative diseases, metabolism and obesity, children's diseases, core technology services, infectious and inflammatory diseases, aging research, pediatric cancer research, Crohn's disease, autism, inflammatory bowel disease, brain injuries, Alzheimer's disease, Parkinson's disease, cardiovascular disease, and calcification
Locations
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Primary
10901 North Torrey Pines Rd.
La Jolla, CA 92037, US
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6400 Sanger Rd.
Orlando, FL 32827, US
Employees at Sanford Burnham Prebys
Updates
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Congratulations to Malin Burnham and Stephen P. Cushman for being named to the San Diego Business Journal’s “8 Over 80,” recognizing their enduring achievements and contributions in business, activism and philanthropy throughout San Diego. Burnham, 96, is an honorary trustee of Sanford Burnham Prebys and has served on the board since 1982. Over his career, Burnham has been an active board member of 16 companies and played a role in the founding of three publicly traded companies. He has been a foundational supporter of the institute. Cushman, 83, is the father of current Sanford Burnham Prebys trustee Lori Moore. President of Cush Enterprises, he has served on more than 70 boards and commissions. More: https://bit.ly/4dgQIcB
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Scientists and clinicians from three local research institutions will converge July 31 to discuss new ways to treat multiple addictions at a Sanford Burnham Prebys open house. The NCI-Designated Cancer Center at Sanford Burnham Prebys will welcome San Diego community members to the institute’s campus for an open house focused on addiction research. The Cancer Center team developed the event in partnership with scientists from Scripps Research and the UC San Diego School of Medicine. The event will take place Wednesday, July 31, 2024, at 3:30 pm at 10901 N. Torrey Pines Road in La Jolla. More information and the online registration form are located on the institute’s website: https://bit.ly/3Yik31i Attendees will meet scientists working to better understand the science behind addiction. A sneak peek of presenters and topics is available on the Sanford Burnham Prebys blog: https://bit.ly/3LDq3tZ #addiction #addictionresearch #cancercenter #sandiego #lajolla #torreypines
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Scientists at Sanford Burnham Prebys, UC San Diego and their international collaborators have reported that more types of lung cells can be infected by SARS-CoV-2 than previously thought, including those without known viral receptors. The research team also reported for the first time that the lung is capable of independently mustering an inflammatory antiviral response without help from the immune system when exposed to SARS-CoV-2. This work is especially timely, as cases of COVID-19 are on the rise in the scientists’ hometown of San Diego during a summertime spike. Looking beyond the region, more than half of the states in the country have reported “very high” or “high” levels of infection, according to the Centers for Disease Control and Prevention. “People used to say that SARS-CoV-2 only infects cells with certain receptors, especially those with the ACE2 receptor known to interact with the infamous SARS-CoV-2 spike protein,” says Evan Snyder, MD, PhD, director of the Center for Stem Cells and Regenerative Medicine and a professor in the Human Genetics Program at Sanford Burnham Prebys. “We demonstrated that when a direct entry point was unavailable, the virus just punches through the cell membrane instead.” In another surprising result, the team discovered that the mini lungs have their own intrinsic “first response” system in reaction to sensing SARS-CoV-2. Even though the mini lungs lack any connection to an immune system, this study shows that lung cells can initiate many of the same biologic and cell signaling changes in response to a viral threat that are observed when the immune system is present. “We showed that it’s not just the immune cells that are becoming over-activated and secreting too much of the pro-inflammatory cytokines that contribute to severe cases of COVID-19,” says Sandra Leibel, MD, MSc, a neonatologist at Rady Children's Hospital-San Diego and an associate professor of Pediatrics at UC San Diego School of Medicine. “The lung cells do this as well.” Read more: https://bit.ly/3zXV09R #covid #covid19 #sarscov2
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Sanford Burnham Prebys reposted this
Congratulations to four Sanford Burnham Prebys GSBS graduate students for being selected to give oral presentations at the California Institute for Regenerative Medicine (CIRM) Trainee Networking Conference on August 13, 2024 based on their submitted abstracts! The conference aims to connect with other investigators who have shared interests and learn from each other. Nahal Azimi (Dr. Ani Deshpande lab) “Multimodal Investigation of Prognostic "Stemness" Attributes in AML" Katya Marchetti (Dr. Karen Ocorr lab) “Identifying Molecular Mechanisms Underlying HLHS - the Roles of ETS Family Transcription Factors" Gabriele Guarnaccia (Dr. Alessandra Sacco lab) “Serum Amyloid Protein A1 (SAA1) Impairs Myogenesis and Myotube Size in Pancreatic Cancer Cachexia” Yu-Ling Linda Chang (Dr. Alexandre Colas lab) “Transcription Factor-Mediated Control of Chromatin Accessibility During Cell Fate Reprogramming”
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Dr. Brooke M. Emerling has been appointed as Leader of the Cancer Metabolism and Microenvironment Program in the NCI-Designated Cancer Center at Sanford Burnham Prebys. Scientists in the program take a comprehensive view of cancer biology, studying how tumors form, grow and spread—guiding their approach to discovering new therapies. Brooke was previously the co-leader for the program, so this will be a seamless transition as she is already well-versed in all program activities and initiatives. Congratulations Brooke! #cancermetabolism #NCIdesignatedcancercenter
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Sanford Burnham Prebys has appointed a new faculty member and promoted two additional faculty members. Douglas Sheffler, Ph.D., was recruited to join the Sanford Burnham Prebys faculty as associate professor in the Center for Therapeutics Discovery, effective August 1. Previously, Sheffler was a research assistant professor working in the lab of Nicholas Cosford, Ph.D., co-director of, and professor in, the Cancer Molecular Therapeutics Program. Cosimo Commisso, Ph.D., was promoted to professor in the Institute’s Cancer Metabolism and Microenvironment Program, effective July 1. He also was appointed deputy director of the Institute’s NCI-designated Cancer Center, effective July 15. Lukas Chavez, Ph.D., was promoted to associate professor in the Cancer Genome and Epigenetics Program, effective July 1. He also is scientific director of the Pediatric Neuro-Oncology Molecular Tumor Board at Rady Children's Hospital-San Diego. Read more: https://bit.ly/3Wok9mS
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We are delighted to announce that Dr. Cosimo Commisso has been appointed as the new Deputy Director of our Cancer Center. In this new role, he will work closely with our Director, Dr. Ze'ev Ronai and the rest of our leadership team to guide research initiatives and collaborations, strategically navigate the Cancer Center to new levels, and drive innovative cancer research discoveries into future therapies. Congratulations Dr. Commisso! #cancerresearch #cancercenter
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Congratulations to Caroline Kumsta, Ph.D., for receiving a $2.9M grant from the National Institute on Aging (NIA). The award will enable Kumsta’s lab to take a deep dive into the fascinating concept of hormesis, where mild stress leads to improved health and a longer life span. Using C. elegans as a model organism, her team will pinpoint the exact timing and specific tissues where the body’s recycling system, #autophagy, needs to be activated to achieve long-term health benefits. Read more: https://bit.ly/3Lm1B0e #cellularrecycling #celegan #aging #agingresearch #lifeexpectancy #nia #nih
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Stem cell scientists: Join the next Southern California Stem Cell Seminar on July 11, 2024 at 9:30 a.m. PDT featuring Michael Lane, Ph.D., of Drexel University. This event is in collaboration with UC San Diego and hosted by Evan Snyder, M.D., Ph.D. Register: https://bit.ly/3S3jrsz #stemcells #stemcellresearch