I presume you can change the controls - although to be fair I never looked, but the control scheme works well for the game (although I had a few terrible games of COD after a 12 hour session on it due to the slight differences).
I really like the plot in Deus Ex:HR but I do rate the original as one of my favourite games of all time so I'm a touch biased. It's set prior to the events of the original so no DE knowledge is required (although there are plenty of references for fans of the original) and if you like your sci-fi you should be intrigued enough. Having said that you get from the story what you put in to a large degree - if you're prepared to read e-mails (on hacked computers) and e-books (which are littered around and some of which contribute to an achievement) you'll have a much more in-depth understanding of the events unfolding and the characters you meet.
As a fan of the series I was not, in any way, disappointed with DE:HR and am looking forward to the DLC.
Hope this helps.