Top critical review
1.0 out of 5 starsPyridoxine form of B6 is toxic and should be changed to all P5P or pyridoxal
Reviewed in the United States on June 27, 2018
I used to think this was one of the best B complex. Unfortunately, new research (The vitamin B6 paradox on researchgate (full study free) from 10/2017 is indicating that the pyridoxine form of B6 INHIBITS the active B6 form P5P so it is actually working against you when you supplement pyridoxine (not P5P) and working instead toward making you more deficient instead in B6 as you take more pyridoxine. It also
was found to significantly increase cell death the more you take in SHSY5Y cells, even in lower doses as well. It is the toxic form. It mentions that Lareb reported cases in which even lower doses (2 mg/day) of vitamin B6 in pyridoxine form gave the same complaints of neuropathy as high doses. So while this is new information that Thorne may not know about yet, it seems that its best to avoid pyridoxine and use only P5P form for B6 and might want to check your other vitamins for the ingredient. According to the european food safety authority, the tolerable upper intake levels for vitamin b6 pyridoxine is 25mg per day and this was before any of this information, and this product contains the maximum but is typically in many other products you may use. Hopefully they will reformulate it and I will certainly consider repurchase and changing the rating if they do, as it was great otherwise. The thorne basic b complex has P5P but has a super high dose of Thiamin and Niacin that some may have issues with so I have generally used Douglas Laboratories B Complex with Metafolin, or occasionally Seeking Health B Minus when I dont need the B12/Folate.
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