Treatment of postconcussional symptoms with CDP-choline
- PMID: 1940965
- DOI: 10.1016/0022-510x(91)90007-t
Treatment of postconcussional symptoms with CDP-choline
Abstract
To evaluate the efficacy of cytidine diphosphoryl choline (CDP-choline) in treating postconcussional symptoms for one month after mild to moderate closed head injury (CHI), we completed a preliminary double blind placebo-controlled study. Fourteen young men admitted to the neurosurgery service after sustaining mild to moderate CHI were randomized to oral CDP-choline (1 g) and placebo control groups which were matched for age, education and severity of impaired consciousness. Baseline (prior to discharge) and one month examinations consisted of a structured postconcussional symptom interview and neuropsychological tests. Results (Wilcoxon test) showed that CDP-choline produced a greater reduction of postconcussional symptoms than placebo (P less than 0.005). Analysis of the neuropsychological findings revealed a significantly greater improvement in recognition memory for designs in the CDP-choline treated patients (P less than 0.02) whereas other changes in test performance did not differ for the two groups. Pending replication in a larger series of patients, our findings suggest that CDP-choline may be effective in treating sequelae of mild to moderate CHI.
Similar articles
-
Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study.Stroke. 1988 Feb;19(2):211-6. doi: 10.1161/01.str.19.2.211. Stroke. 1988. PMID: 3278412 Clinical Trial.
-
Effects of CDP-choline on the recovery of patients with head injury.J Neurol Sci. 1991 Jul;103 Suppl:S15-8. doi: 10.1016/0022-510x(91)90003-p. J Neurol Sci. 1991. PMID: 1940960 Clinical Trial.
-
Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study.Neuropsychopharmacology. 2010 Apr;35(5):1165-73. doi: 10.1038/npp.2009.221. Epub 2009 Dec 30. Neuropsychopharmacology. 2010. PMID: 20043005 Free PMC article. Clinical Trial.
-
CDP-choline: pharmacological and clinical review.Methods Find Exp Clin Pharmacol. 1995 Oct;17 Suppl B:1-54. Methods Find Exp Clin Pharmacol. 1995. PMID: 8709678 Review.
-
Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.Cochrane Database Syst Rev. 2000;(2):CD000269. doi: 10.1002/14651858.CD000269. Cochrane Database Syst Rev. 2000. Update in: Cochrane Database Syst Rev. 2000;(4):CD000269. doi: 10.1002/14651858.CD000269. PMID: 10796523 Updated. Review.
Cited by
-
Citicoline for the Management of Patients with Traumatic Brain Injury in the Acute Phase: A Systematic Review and Meta-Analysis.Life (Basel). 2023 Jan 29;13(2):369. doi: 10.3390/life13020369. Life (Basel). 2023. PMID: 36836726 Free PMC article. Review.
-
Citicoline: pharmacological and clinical review, 2022 update.Rev Neurol. 2022 Nov 30;75(s05):S1-S89. doi: 10.33588/rn.75s05.2022311. Rev Neurol. 2022. PMID: 36544369 Free PMC article. Review.
-
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities.Int J Mol Sci. 2021 Oct 20;22(21):11313. doi: 10.3390/ijms222111313. Int J Mol Sci. 2021. PMID: 34768742 Free PMC article. Review.
-
Role of Citicoline in the Management of Traumatic Brain Injury.Pharmaceuticals (Basel). 2021 Apr 26;14(5):410. doi: 10.3390/ph14050410. Pharmaceuticals (Basel). 2021. PMID: 33926011 Free PMC article. Review.
-
Citicoline in severe traumatic brain injury: indications for improved outcome : A retrospective matched pair analysis from 14 Austrian trauma centers.Wien Klin Wochenschr. 2018 Jan;130(1-2):37-44. doi: 10.1007/s00508-017-1240-9. Epub 2017 Jul 27. Wien Klin Wochenschr. 2018. PMID: 28752349
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
