After returning from death, Thanos decided to give twelve different people, who had ambitions to rule the world, special suits which gave super-powers and making John King, as Cancer, their leader. Their mission was to steal numerous powerful items, which Thanos wanted to take out from Earth in order to supposedly bring balance to the planet and the entire cosmos.^[1]

When the Avengers prevented Zodiac from stealing an Ultimate Nullifier, Gemini, Virgo, Libra, Pisces and Leo them to the S.H.I.E.L.D. Helicarrier in order to retrieve the weapon.^[2] After Leo died of a heart attack during his fight with the Hulk, the energies of from his suit passed by Iron Man's armor, giving him a chance to analyse them. Using a sonic disruptor from the data he received, Iron Man was able to shut down their special costumes and leave them powerless, Thanos appeared with the objective to kill the Avengers for interfering in his plan.^[3] When Maria Hill activated the Helicarrier's self-destruct in an attempt to kill Thanos, the Zodiac's master left them to die in the explosion. Cancer was later apprehended and interrogated by the Avengers in order to find out Thanos' plan.^[4] The fate of the other five surviving members is unknown.

Zodiac team members' special battlesuits

• According to Captain America, when mentioning the identities of the Zodiac members, one of them was an old bodyguard of the Kingpin, another previously worked for the Mandarin, and another was a Hydra agent. It was never stated which of these members was associated with these identities.^[4]