Featured Characters:

• The Hulk (First appearance)

Supporting Characters:

• Pantheon (First appearance)
  • Atlanta (First appearance)
  • Agamemnon (First appearance)
  • Ajax (First appearance)
  • Hector (First appearance)
  • Ulysses (First appearance)
  • Paris (First appearance)

Antagonists:

• Piecemeal (First appearance)
• Trauma (First appearance)
• Lazarus (First appearance)
• U-Foes (First appearance)
  • Vector (First appearance)
  • Ironclad (First appearance)
  • X-Ray (First appearance)
• Maestro (First appearance) (death)

Other Characters:

• Rick Jones (First appearance)

Locations:

• Earth-TRN1031 (First appearance)
  • United States of America
    • Nevada
      • The Mount
  • Scotland
  • Antarctica
    • Alternate Future Imperfect

Items:

• Gamma Bomb

Vehicles:

• 
  

The cut scenes between levels do not explain much of the game's storyline. The game begins with the Hulk begin captured by the Pantheon and breaking free just as their cargo ship lands in the group's mountain headquarters. In the first four levels, the player battles inside the headquarters, until the Pantheon members Atalanta, Ulysses, Ajax and Hector are located and defeated. After each member is defeated, they become your ally and can temporary appear on screen to assist the player. The game then shifts to several more side-scrolling levels where the player battles super-villains such as Piecemeal, Trauma, Lazarus, the U-Foes and the Maestro.

• Vapor is shown in the manual as a member of the U-Foes you can face, however they do not show up in the game.