The Tablet of Death and Entropy was a Lemurian artifact, a stone tablet with magical ancient runes inscribed on its surface. It was stolen by Overdrive from a museum under the orders of Mister Negative. He was foiled by Spider-Man before he could deliver it.^[1] Mister Negative was able to acquire it by paying for Detective Willowby to remove it from the NYPD evidence locker. He used a formula taken from the tablet to create Devil's Breath, a powerful poison that targeted specific DNA. He stole a sample of blood from Bruno Karnelli in order to kill the members of the Maggia. Spider-Man rescued Karnelli and destroyed the Tablet, but Mister Negative pointed out that he had already written down the formula.^[2][3]

After events with Sin-Eater and regaining his body, Mister Negative traded the Tablet to Wilson Fisk in exchange for his previous territories in Chinatown and, Lower East side. However, despite a fair trade, Fisk offered more territory in New York in exchange for hunting Spider-Man to retrieve the Tablet's twin half, and agreed to the offer after being presented his stiff competition with other New York crime lords.^[4]

• The Tablet of Death and Entropy is the sister stone of the Tablet of Life and Time.