The Baxter Building was one of the first targets Deadpool hit at the start of his killing spree against super-humans.

Susan Storm's husband, Mr. Fantastic, died in her arms. She went to the room where Deadpool was facing the Human Torch after hearing an explosion, and witnessed Deadpool decapitating her brother. She created a force field inside Deadpool's head and expanded it in order to blow his head up, but when she wasn't on guard, Deadpool stabbed her from behind after regenerating.^[1]