Featured Characters:

• The Human Torch (Johnny Storm)
• The Thing (Ben Grimm)

Supporting Characters:

• Alicia Masters

Antagonists:

• Chief Examiner
• Doctor Doom (Victor von Doom)
• Xandu
• Blob (Fred Dukes)
• Circus of Crime
  • Ringmaster (Maynard Tiboldt)

Other Characters:

• 
  

Locations:

• Earth-616
  • Latveria

Items:

• Fantastic Four Uniforms
• Doctor Doom's Armor
• Ringmaster's Hat

Vehicles:

• 
  

The Human Torch and the Thing must work together in order to rescue Alicia Masters from Dr. Doom's Latverian castle.

A tie-in comic was released along side the game.

Despite the title's claim that the game featured The Fantastic Four, only The Thing and The Human Torch are featured in the game.