Featured Characters:

• Secret Warriors (First appearance)
  • Ms. Marvel (Kamala Khan) (Main story and flashback) (Origin revealed) (Joins)
  • Squirrel Girl (Doreen Green) (Joins)
  • Inferno (Dante Pertuz) (First appearance) (Main story and flashback) (Joins)
  • Quake (Agent Daisy Johnson) (Leaves S.H.I.E.L.D.) (Joins)
  • Patriot (Agent Shaun Lucas) (Leaves S.H.I.E.L.D.) (Joins)
  • Ms. America Chavez (First appearance) (Main story and flashback) (Joins)

Supporting Characters:

• Captain Marvel (Carol Danvers) (First appearance)
• Muneeba Khan (First appearance)
• Squirrel Scouts
  • Tippy-Toe
  • Numerous unnamed others
• Elena Chavez (First appearance; dies) (Only in flashback)
• Amalia Chavez (First appearance; dies) (Only in flashback)
• Four unnamed Nuhumans (First appearance)
• Lockjaw (First appearance)
• Captain America (Steve Rogers) (First appearance)

Antagonists:

• Kree Empire
  • Exile (Victor Kohl) (Main story and flashback)
  • Hala the Accuser (First appearance) (Main story and flashback)
  • Sheath (Only in flashback)
  • Numerous unidentified others (Main story and flashback)

Other Characters:

• Iron Man (Tony Stark) (Toy)
• Numerous unnamed New Jerseyans
• President Franklin D. Roosevelt (Mentioned)
• Numerous unnamed New Yorkers
• S.H.I.E.L.D.
• Wilson (First appearance)
• NYPD
• Naani Khala (Mentioned)
• Yusuf Khan (Mentioned)
• Yumi (Mentioned) (Topical Reference)
• Mr. Pertuz (First appearance; on-screen)
• Mrs. Pertuz (First appearance; on-screen)
• Avengers (Mentioned)
• Secret Avengers (Mentioned)

Races and Species:

• Human-Inhuman Hybrids (Main story and flashback)
• Humans (Main story and flashback)
• Human-Kree Hybrids
• Dogs (Toy)
• Inhumans (Mentioned)
• Squirrels
• Fuertonas
• Kree (Main story and flashback)
• Inhuman Dogs

Locations:

• Earth-TRN684 (Main story and flashback)
  • Earth (Main story and flashback)
    • United States of America (Main story and flashback)
      • New Jersey (First appearance) (Main story and flashback)
        • Jersey City (First appearance) (Main story and flashback)
          • Liberty State Park (First appearance)
          • Grove Street (First appearance)
            • Khan Family Residence (First appearance)
          • Hamilton Park (First appearance)
            • Coles Street (First appearance)
              • Coles Academic High School (First appearance)
          • Waterfront (First appearance) (Only in flashback)
      • New York
        • New York City
          • Manhattan
            • Central Park
            • Midtown
              • Stark Tower, Columbus Circle (Mentioned)
          • Brooklyn (First appearance)
            • Gravesend (First appearance)
              • Stillwell Avenue (First appearance)
                • Wilson's Auto (First appearance)
          • Upper New York Bay (First appearance)
            • Governors Island (First appearance)
              • Triskelion (First appearance)
    • Earth Orbit (First appearance) (Main story and flashback)
      • Moon (First appearance) (Main story and flashback)
      • Alpha Flight Low-Orbit Space Station (First appearance)
  • Planeta Fuertona (First appearance) (Only in flashback)
  • Asgard (Mentioned)

Items:

• Ms. Marvel's Suit
• Iron Man Armor Model 37 (Bleeding Edge Armor) (Toy)
• Captain Marvel's Suit (First appearance)
• Darkforce
• Quake's Gauntlets
• Patriot's Uniform and Shield
• Terrigen Mist (First appearance) (Only in flashback)
• Locator Pendant (First appearance)
• Captain America's Uniform and Shield (First appearance)

Vehicles:

• S.H.I.E.L.D. Helicarrier (First appearance)
• S.H.I.E.L.D. Flying Cars
• Ms. America's Motorcycle (First appearance)
• Squirrel Girl's Scooter
• Kree Imperial Cruiser (First appearance) (Destruction)
• Quinjet (First appearance) (Destruction)

• Kim Raver as Captain Marvel / Carol Danvers^[1]
• Kathreen Khavari as Ms. Marvel / Kamala Khan^[1]
• Tyler Posey as Inferno / Dante Pertuz^[1]
• Milana Vayntrub as Squirrel Girl / Doreen Green^[1]
• Chloe Bennet as Quake / Daisy Johnson^[1]
• Cierra Ramirez as Ms. America Chavez^[1]
• Dove Cameron as Ghost-Spider / Gwen Stacy^[1]
• Kamil McFadden as Patriot / Rayshaun Lucas^[1]
• Skai Jackson as Gloria "Glory" Grant^[1]
• Steven Weber as Captain George Stacy^[1]
• Dee Bradley Baker as Lockjaw & Tippy-Toe^[1]
• Ming-Na Wen as Hala the Accuser^[1]
• Booboo Stewart as Exile / Victor Kohl^[1]

• This film was preceded by a web series called Marvel Rising: Initiation, which is intended to start a new multi-platform animation franchise.^[1]

• A Portion of the cast will be voicing characters they've portrayed before or are going to portray in the future:
  • Chloe Bennett previously portrayed Daisy Johnson in the ABC series Marvel's Agents of S.H.I.E.L.D.
    • Ming-Na Wen also previously starred alongside Bennett in that same series, as Melinda May, while Dove Cameron would later star alongside them as Ruby Hale.
  • Dove Cameron previously voiced Spider-Gwen in the Ultimate Spider-Man animated series.
    • Both Dee Bradley Baker and Steven Weber previously voiced several characters in that series, while Skai Jackson appeared as Zuri Ross in the episode "Halloween Night at the Museum", which was a crossover with the Disney Channel live-action sitcom Jessie.
  • Kathreen Khavari previously voiced Kamala Khan in the Marvel's Avengers Assemble animated series.
  • Milana Vayntrub was planned to portray Squirrel Girl in the now cancelled series Marvel's New Warriors.