Featured Characters:

• The Fantastic Four (First appearance)
  • Mr. Fantastic (Reed Richards) (First appearance)
  • Invisible Woman (Susan Storm) (First appearance)
  • Human Torch (Johnny Storm) (First appearance)
  • The Thing (Ben Grimm) (First appearance)

Supporting Characters:

• Alicia Masters (First appearance)
• S.H.I.E.L.D. (First appearance)
  • Nick Fury (First appearance)

Antagonists:

• Doctor Doom (Victor Von Doom) (First appearance)
• Doombot (First appearance)
• Annihilus (First appearance)
• Dragon Man (First appearance)
• Blastaar (First appearance)
• Puppet Master (Phillip Masters) (First appearance)
• Diablo (Esteban Corazón De Ablo) (First appearance)
• Mole Man (Harvey Elder) (First appearance)
• Yancy Street Gang (First appearance)

Other Characters:

• Petunia Grimm (Mentioned)

Races and Species:

• Humans (First appearance)

Locations:

• Earth-TRN1004 (First appearance)
  • Earth (First appearance)
    • United States of America (First appearance)
      • New York (First appearance)
        • New York City (First appearance)
          • Manhattan (First appearance)
            • Baxter Building (First appearance)
      • Colorado (First appearance)
        • Rocky Mountains (First appearance)
          • Von Doom Industries Medical Center (First appearance)
          • Vault (First appearance)
    • Mexico (First appearance)
      • Tikal (First appearance)
  • Earth Orbit (First appearance)
    • Von Doom Industries Space Station (First appearance)

Items:

• Adamantium
• Psychic Clay
• Cosmic Storm Machine

Vehicles:

Bonus storyline[]

Featured Characters:

• The Fantastic Four (First appearance)
  • Mr. Fantastic (Reed Richards) (First appearance)
  • Invisible Woman (Susan Storm) (First appearance)
  • Human Torch (Johnny Storm) (First appearance)
  • The Thing (Ben Grimm) (First appearance)

Antagonists:

• Doctor Doom (Victor Von Doom) (First appearance)

Locations:

• Unidentified reality (First appearance)
  • Latveria (First appearance)
  • Hell (First appearance)

At the Baxter Building, Ben Grimm sees the events happening to him before his eyes.

• Ioan Gruffudd as Mr. Fantastic (Reed Richards)
• Jessica Alba as Invisible Woman (Susan Storm)
• Chris Evans as Human Torch (Johnny Storm)
• Michael Chiklis as The Thing (Ben Grimm)
• Julian McMahon as Victor Von Doom
• Cree Summer as Alicia Masters
• Andre Ware as Nick Fury
• Lex Lang as Annihilus

• Despite the expanded storyline and roster of villains, the game borrows heavily from the film it is based on. The main timeline divergence, in contrast to the additional material and shared story elements, being Victor von Doom's continued position as his company's CEO after the Fantastic Four's first public appearance.