Abstract
Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile, periodontal disease is a chronic inflammatory disease caused by infection with periodontal pathogens such as P. gingivalis (Porphyromonas gingivalis). Several studies have reported association between periodontal infection and atherosclerosis, but direct investigation about the effects of periodontal treatment on atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between periodontal disease and atherosclerosis under collaborative with medical and dental care. A prospective, multicentre, observational study was conducted including 38 medical patients with lifestyle-related diseases in the stable period under consultation at participating medical clinics and 92 periodontal patients not undergoing medical treatment but who were consulting at participating dental clinics. Systemic and periodontal examinations were performed before and after periodontal treatment. At baseline, LDL-C (low-density lipoprotein cholesterol) levels and percentage (%) of mobile teeth were positively related to plasma IgG (immunoglobulin) antibody titer against P. gingivalis with multivariate analysis. Corresponding to improvements in periodontal clinical parameters after treatment, right and left max IMT (maximum intima-media thickness) levels were decreased significantly after treatment (SPT-S: start of supportive periodontal therapy, SPT-1y: at 1 year under SPT, and SPT-3y: at 3 years under SPT). The present study has clarified our previous univariate analysis results, wherein P. gingivalis infection was positively associated with progression of atherosclerosis. Thus, routine screening using plasma IgG antibody titer against P. gingivalis and periodontal treatment under collaborative with medical and dental care may prevent cardiovascular accidents caused by atherosclerosis.
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Acknowledgements
This study was supported by Grant-in-planning for Advanced Research (H22) from Japanese Society of Periodontology. Periodontitis and Atherosclerosis Project–Tokyo and Chiba Consortiums include: Kiyotaka Fujii (Kashiwado Memorial Foundation Port square Kashiwado Clinic, Chiba), Tooru Hanai (Kensei Clinic, Chiba), Kouya Honda (Honda Medical Clinic, Tokyo), Yoshichika Horiuchi (Horiuchi Dental Clinic, Tokyo), Hiroshi Inoue (Tsubasa Dental Clinic, Tokyo), Kiyoo Ishige (Tendai Dental Clinic, Chiba), Shinichi Itoh (Ito Clinic, Tokyo), Sachiho Iwatsuka (Hotaruno Dental Clinic, Chiba), Tomoko Kakugawa (Tomiya Central Hospital, Miyagi), Hideto Komai (Eiken Medical Dental Clinic, Tokyo), Chikara Morimoto (Morimoto Dental Office, Tokyo), Mitsutaka Motoyoshi (Memorial Hospital of Kazusa, Tokyo), Masato Nakamura (Nakamura Clinic, Chiba), Mikiko Niida (Naganawa Dental Clinic, Chiba), Ryuji Numaguchi (Numaguchi Dental Office, Tokyo), Kiyomi Oono (Oono Dental Clinic, Chiba), Hidetoshi Sakai (Sakai Dental Clinic, Chiba), Yasunari Sakomura (Sakomura Medical Clinic, Tokyo), Takaaki Shinohara (Shinohara Dental Clinic, Tokyo), Yuichi Takakaze (Takakaze Dental Clinic, Tokyo), Yukio Tsuruta (Tsuruta Clinic, Tokyo), Daigaku Uchida (Hotaruno Central Internal Medicine, Chiba), Norihide Ueno (Ushigomekagurazaka Dental Office, Tokyo), and Osamu Yasuda (Clinic Yasuda, Tokyo).
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UMIN-CTR: UMIN000008071.
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Kudo, C., Shin, W.S., Sasaki, N. et al. Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study. Odontology 106, 316–327 (2018). https://doi.org/10.1007/s10266-017-0331-4
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DOI: https://doi.org/10.1007/s10266-017-0331-4