Maria Loustau

Paris et périphérie Coordonnées
2 k abonnés + de 500 relations

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    Conseil en management et Gestion de projet

À propos

Currently R&D Director, I’m a result-oriented professional with great eye for detail and…

Activité

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Expérience et formation

  • Invectys

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Licences et certifications

Brevets

  • Single domain antibodies directed against LILRB2

    Demande de dépôt le FR EP19306148

    Single-domain antibodies (sdAbs) directed against Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) intended to target solid tumors and reprogram the tumor microenvironment, demonstrated to inhibit HLA-G and ANGPT-2 binding to LILRB2.

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  • Chimeric antigen receptors against HLA-G

    Demande de dépôt le FR PCT/EP19305809

    Chimeric antigen receptors (CAR) derived from the Invectys’ HLA-G specific monoclonal antibodies. IP on CAR-T cells against HLA-G isoforms and their applications against multiple cancers.

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  • Method to assess CAR functionality

    Demande de dépôt le FR PCT/EP18306152

    Very simple assay based on the phenomenon of trogocytosis developed to determine paratopes and core chains combination to allow rapidly specific target recognition and proper activation of expressing CAR-T cells.

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  • Anti-HLA-G specific antibodies

    Émis le FR PCT/EP2017/063503

    The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA- G) protein and raised against an immunogenic peptide derived from the a3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies. A particular embodiment refers to the monoclonal antibody with the arbitrary designation 15E7 for which the sequence is provided. Also a anti-HLA-G…

    The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA- G) protein and raised against an immunogenic peptide derived from the a3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies. A particular embodiment refers to the monoclonal antibody with the arbitrary designation 15E7 for which the sequence is provided. Also a anti-HLA-G single-chain antibody gene library was generated and six specific binders were identified from that library.

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  • Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof

    Émis le FR WO/2014/072534

    An antibody or antigen-binding fragment thereof which specifically binds the α3 domain of a HLA-G protein, in particular binds the β2-microglobulin free HLA-G protein exhibiting an α3 domain. The nucleic acid molecules encoding a human HLA-G α3 domain polypeptide, which is selected from a group of specific sequences, and vectors for the cloning and/or expression of such nucleic acid molecules, recombined cells or cell lines and compositions for use in a host in need thereof to interfere with…

    An antibody or antigen-binding fragment thereof which specifically binds the α3 domain of a HLA-G protein, in particular binds the β2-microglobulin free HLA-G protein exhibiting an α3 domain. The nucleic acid molecules encoding a human HLA-G α3 domain polypeptide, which is selected from a group of specific sequences, and vectors for the cloning and/or expression of such nucleic acid molecules, recombined cells or cell lines and compositions for use in a host in need thereof to interfere with and neutralize the immune down-regulation due to HLA-G proteins, and/or improving or treating conditions showing HLA-G+ lesions, and/or improving or treating a neoplasic condition or disease. A method of producing the antibody or antigen-binding fragment thereof, immunogenic compositions for use to elicit in a host an immune response against the α3 domain of HLA-G protein, and an in vitro method for detecting HLA-G protein in a sample are also described.

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