The Metropsis Edition (v2.*) for Clinical Research is Cambridge Research Systems' visual function assessment suite for macOS. Fully powered by Psykinematix, it is a modular, expandable and configurable testing system suitable for:
  • clinical research,
  • applied vision research,
  • drug trials,
  • screening,
  • sports science,
  • human factors research.
It includes a "Nurse" interface on top of Psykinematix and a remote App for iPad to control and monitor the tests. It also comes with ready-to-use standard clinical tests (visual acuity, spatial and temporal contrast sensitivity, color discrimination, binocular vision, and many more) and can generate PDF reports after each test session.

Available exclusively from Cambridge Research Systems Ltd or its official distributors

Ready-to-use Clinical Tests
AMD Glare Amblyopia
Visual Acuity Spatial Contrast Sensitivity Temporal Contrast Sensitivity
Stereo Acuity Colour Discrimination Rod Sensitivity
Custom Test Design

Metropsis for macOS is already used in clinical trials at multiple research centers in the UK, USA, Japan, Canada, France, Germany and Portugal, including:
Moorfields Eye Hospital, London
Nuffield Laboratory of Ophthalmology, Oxford
Kellogg Eye Centre, Ann Arbour
Institut de la Vision, Paris
Institute for Ophthalmic Research, Tubingen
Emory Eye Centre, Atlanta
Department of Ophthalmology, University of Colorado
Department of Medicine and Optometry, Linnaeus University
Faculty of Medicine, University of Coimbra
Published studies that made use of Metropsis for macOS:

Hammond Jr BR, Leathers TA, Wooten BR, Renzi-Hammond LM (2023) Contrast sensitivity functions measured using simple optics and computer testing. Ophthalmic and Physiological Optics

Bell ELS, Hastings GD, Nguyen LC, Applegate RA, Marsack JD (2023) Utilising a visual image quality metric to optimise spectacle prescriptions for eyes with keratoconus. Ophthalmic and Physiological Optics

Michaelides M, Hirji N, Wong SC, Besirli CG, Zaman S, Kumaran N, Georgiadis A, Smith AJ, Ripamonti C, Gottlob I, Robson AG, Thiadens A, Henderson RH, Fleck P, Anglade E, Dong X, Capuano G, Lu W, Berry P, Kane T, Naylor S, Georgiou M, Kalitzeos A, Ali RR, Forbes A, Bainbridge J (2023) First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children With CNGB3-associated Achromatopsia. American Journal of Ophthalmology, Volume 253, pp. 243-251

Huchzermeyer C, Fars J, Kremers J, Kühlewein L, Kempf M, Ott S, Stingl K, Stingl K (2023) Photoreceptor-Specific Temporal Contrast Sensitivities in RP1L1-Associated Occult Macular Dystrophy. Investigative Ophthalmology & Visual Science 64 (33)

Kremers J, Aher AJ, Huchzermeyer C (2023) Modulation of flash ERGs by dynamic backgrounds. Doc Ophthalmol 146, 33–51

Blume C, Cajochen C, Schöllhorn I et al. (2023) Effects of calibrated blue–yellow changes in light on the human circadian clock. Nat Hum Behav.

Hirami, Yasuhiko et al. (2023) Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa. Cell Stem Cell, 30(12):1585-1596.e6.

Fars J, Fernandes TP, Huchzermeyer C et al. (2022) Chromatic discrimination measures in mature observers depend on the response window. Sci Rep 12, 9072.

Jolly JK, Pratt L, More AK, Kwan J, Jones RL, MacLaren RE, Aslam S (2022) The Effect of Cataract on Color Vision Measurement with the Low-Vision Cambridge Colour Test: Providing an Adjustment Factor for Clinical Trials. Ophthalmology Science 2(2), 100153, ISSN 2666-9145.

Jolly JK, Simunovic MP, Dubis AM, Josan AS, Robson AG, Bellini MP, Bloch E, Georgiadis O, da Cruz L, Bridge H, MacLaren RE (2021) Structural and Functional Characteristics of Color Vision Changes in Choroideremia. Frontiers in Neuroscience 15.

Domínguez-Vicent A, Helghe E, Wahlberg Ramsay M, Venkataraman AP (2021) Photopic and Mesopic Contrast Sensitivity Function in the Presence of Glare and the Effect of Filters in Young Healthy Adults. Frontiers in Psychology 12.

Jolly JK (2020) Assessment and evaluation of visual function measurement in inherited retinal degeneration; focusing on optimisation. PhD thesis, University of Oxford.

Ryan DS, Sia RK, Eaddy JB, Logan LA, Familoni JO, Beydoun H, Rodgers SB, Rivers BA (2020) Preliminary evaluation of the VIsion PERformance (VIPER) simulator. Military Medical Research volume 7, Article number: 2

Motz CT, Chesler KC, Allen RS, Bales KL, Mees LM, Feola AJ, Maa AY, Olson DE, Thule PM, Iuvone PM, Hendrick AM, Pardue MT (2020) Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy. Diabetes 69(7): 1518-1527. https://doi.org/10.2337/db19-0869

Georgiou M, Singh N, Kane T, Robson AG, Kalitzeos A, Hirji N, Webster AR, Dubra A, Carroll J, Michaelides M (2020) Photoreceptor Structure in GNAT2-Associated Achromatopsia. Investigative Ophthalmology & Visual Science, Vol. 61(40). doi:https://doi.org/10.1167/iovs.61.3.40

Huchzermeyer C, Fars J, Stöhr H, Kremers J (2020) Neue Techniken zur Quantifizierung des Farbsinns bei Störungen der Zapfenfunktion – Cambridge-Color-Test und photorezeptorspezifische zeitliche Kontrastempfindlichkeit bei Patient/Innen mit heterozygoten RP1L1- und RPGR- Mutationen. Der Ophthalmologe, https://doi.org/10.1007/s00347-020-01119-0

Patterson Gentile C, Aguirre GK (2020) A neural correlate of visual discomfort from flicker. Journal of Vision, Vol.20, 11. doi:https://doi.org/10.1167/jov.20.7.11

Georgiou M, Robson AG, Singh N, Pontikos N, Kane T, Hirji N, Ripamonti C, Rotsos T, Dubra A, Kalitzeos A, Webster AR, Carroll J, Michaelides M (2019) Deep Phenotyping of PDE6C-Associated Achromatopsia. Investigative Ophthalmology & Visual Science December 2019, Vol.60, 5112-5123. doi:https://doi.org/10.1167/iovs.19-27761

Kumaran N, Ripamonti C, Kalitzeos A, Rubin GS, Bainbridge JWB, Michaelides M (2018) Severe Loss of Tritan Color Discrimination in RPE65 Associated Leber Congenital Amaurosis. Investigative Ophthalmology & Visual Science, Vol.59:85-93. doi:https://doi.org/10.1167/iovs.17-22905

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System Requirements

Minimum:Mac OS X 10.6, Intel Core, 256MB VRAM
Better:Mac OS X 10.8.5, Intel Core Duo 2Ghz, 512MB VRAM, or better
Recommended :macOS 10.12 (Sierra), 2.4Ghz Intel Core i7, 1GB VRAM, or better
Incompatible with :M1 processor, Rosetta 2

Release Notes

Metropsis Edition Version 2.5.1       Released:  December 15, 2020

Prevent launch under Rosetta 2 on M1 computers due to instructions incompatibility with Intel processors
Metropsis Edition Version 2.5       Released:  November 12, 2020

Bug fixes, improvements and 64-bit compatibility with macOS 11 "Big Sur"
Metropsis Edition Version 2.4       Released:  October 28, 2019

Bug fixes, improvements and 64-bit compatibility with macOS 10.15 "Catalina"
Metropsis Edition Version 2.3       Released:  October 18, 2018

Bug fixes, improvements & compatibility with macOS 10.14 "Mojave"
Metropsis Edition Version 2.2     Released: September 25, 2017

Full Compatibility with macOS 10.13 "High Sierra"
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