Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen
- PMID: 12397186
- PMCID: PMC137901
- DOI: 10.1073/pnas.172501299
Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen
Abstract
Streptococcus mutans is the leading cause of dental caries (tooth decay) worldwide and is considered to be the most cariogenic of all of the oral streptococci. The genome of S. mutans UA159, a serotype c strain, has been completely sequenced and is composed of 2,030,936 base pairs. It contains 1,963 ORFs, 63% of which have been assigned putative functions. The genome analysis provides further insight into how S. mutans has adapted to surviving the oral environment through resource acquisition, defense against host factors, and use of gene products that maintain its niche against microbial competitors. S. mutans metabolizes a wide variety of carbohydrates via nonoxidative pathways, and all of these pathways have been identified, along with the associated transport systems whose genes account for almost 15% of the genome. Virulence genes associated with extracellular adherent glucan production, adhesins, acid tolerance, proteases, and putative hemolysins have been identified. Strain UA159 is naturally competent and contains all of the genes essential for competence and quorum sensing. Mobile genetic elements in the form of IS elements and transposons are prominent in the genome and include a previously uncharacterized conjugative transposon and a composite transposon containing genes for the synthesis of antibiotics of the gramicidin/bacitracin family; however, no bacteriophage genomes are present.
Figures
Similar articles
-
Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content.BMC Genomics. 2009 Aug 5;10:358. doi: 10.1186/1471-2164-10-358. BMC Genomics. 2009. PMID: 19656368 Free PMC article.
-
Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans.Mol Oral Microbiol. 2018 Jun;33(3):257-269. doi: 10.1111/omi.12222. Epub 2018 Apr 17. Mol Oral Microbiol. 2018. PMID: 29524318 Free PMC article.
-
Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans.mSphere. 2020 Jan 8;5(1):e00764-19. doi: 10.1128/mSphere.00764-19. mSphere. 2020. PMID: 31915219 Free PMC article.
-
Inhibition of Streptococcus mutans biofilm formation by strategies targeting the metabolism of exopolysaccharides.Crit Rev Microbiol. 2021 Sep;47(5):667-677. doi: 10.1080/1040841X.2021.1915959. Epub 2021 May 3. Crit Rev Microbiol. 2021. PMID: 33938347 Review.
-
[Streptococcus mutans and oral streptococci in dental plaque].Can J Microbiol. 2011 Jan;57(1):1-20. doi: 10.1139/w10-095. Can J Microbiol. 2011. PMID: 21217792 Review. French.
Cited by
-
Intraspecies interactions of Streptococcus mutans impact biofilm architecture and virulence determinants in childhood dental caries.mSphere. 2024 Jul 30;9(7):e0077823. doi: 10.1128/msphere.00778-23. Epub 2024 Jul 11. mSphere. 2024. PMID: 38990043 Free PMC article.
-
Ribosomal-processing cysteine protease homolog modulates Streptococcus mutans glucan production and interkingdom interactions.J Bacteriol. 2024 Jul 25;206(7):e0010424. doi: 10.1128/jb.00104-24. Epub 2024 Jun 20. J Bacteriol. 2024. PMID: 38899897
-
Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies.BMC Oral Health. 2024 Jun 5;24(1):662. doi: 10.1186/s12903-024-04263-0. BMC Oral Health. 2024. PMID: 38840232 Free PMC article. Review.
-
Isolation and Characterisation of Streptococcus spp. with Human Milk Oligosaccharides Utilization Capacity from Human Milk.Foods. 2024 Apr 23;13(9):1291. doi: 10.3390/foods13091291. Foods. 2024. PMID: 38731662 Free PMC article.
-
Ancient Genomes From Bronze Age Remains Reveal Deep Diversity and Recent Adaptive Episodes for Human Oral Pathobionts.Mol Biol Evol. 2024 Mar 1;41(3):msae017. doi: 10.1093/molbev/msae017. Mol Biol Evol. 2024. PMID: 38533900 Free PMC article.
References
-
- World Health Organization, (1994) WHO/28 (W.H.O., Geneva).
-
- Herzberg M. C. (2000) in Streptococcal Infections, eds. Stevens, D. L. & Kaplan, E. L. (Oxford Univ. Press, New York), pp. 333–370.
-
- Burne R. A. (1998) J. Dent. Res. 77, 443-452. - PubMed
-
- Colby S. M. & Russell, R. R. B. (1997) J. Appl. Microbiol. Symp. Suppl. 83, 80s-88s. - PubMed
Publication types
MeSH terms
Substances
Associated data
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases