States of oral health and disease reflect the compositional and functional capacities of, as
well as the interspecies interactions within, the oral microbiota. The oral cavity exists as a�…

Bacteria belonging to the genus Streptococcus are the first inhabitants of the oral cavity,
which can be acquired right after birth and thus play an important role in the assembly of the�…

For millions of years, our resident microbes have coevolved and coexisted with us in a
mostly harmonious symbiotic relationship. We are not distinct entities from our microbiome�…

As a major etiological agent of human dental caries, Streptococcus mutans resides primarily
in biofilms that form on the tooth surfaces, also known as dental plaque. In addition to caries�…

The human trophic level (HTL) during the Pleistocene and its degree of variability serve,
explicitly or tacitly, as the basis of many explanations for human evolution, behavior, and�…

Despite the enormous contributions of the bacterial paradigms Escherichia coli and Bacillus
subtilis to basic and applied research, it is well known that no single organism can be a�…

Background Dental caries is a microbe and sugar-mediated biofilm-dependent oral disease.
Of particular significance, a virulent type of dental caries, known as severe early childhood�…

The oral microbiome, forming a biofilm that covers the oral structures, contains a high
number of microorganisms. Biofilm formation starts from the salivary pellicle that allows�…

Dental caries is an infectious disease that causes tooth decay. The high prevalence of
dental caries in recent humans is attributed to more frequent consumption of plant foods rich�…

Background The increasing availability of microbial genomes and environmental shotgun
metagenomes provides unprecedented access to the genomic differences within related�…